Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin

Abstract Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellul...

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Bibliografiska uppgifter

Huvudupphov:	Kohei Fujii, Yuya Fujishima, Shunbun Kita, Keitaro Kawada, Keita Fukuoka, Taka-aki Sakaue, Tomonori Okita, Emi Kawada-Horitani, Hirofumi Nagao, Shiro Fukuda, Norikazu Maeda, Hitoshi Nishizawa, Iichiro Shimomura
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2024-02-01
Serie:	Scientific Reports
Länkar:	https://doi.org/10.1038/s41598-024-51935-6
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