Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients

Head and neck squamous cell carcinoma (HNSCC) patients treated with high-dose cisplatin concurrently with radiotherapy (hdCis-RT) commonly suffer kidney injury leading to acute and chronic kidney disease (AKD and CKD, respectively). We conducted a retrospective analysis of renal function and kidney...

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Hauptverfasser:	K.A. Mapuskar, G. Vasquez Martinez, C.F. Pulliam, M.S. Petronek, E.J. Steinbach, V. Monga, M. Furqan, J.G. Jetton, D.P. Saunders, A. Pearce, S. Davidson, L. Pitre, N.E. Dunlap, R. Fairbanks, C.M. Lee, S.L. Mott, K.L. Bodeker, Huang Cl, J.M. Buatti, C.M. Anderson, R.A. Beardsley, J.T. Holmlund, D. Zepeda-Orozco, D.R. Spitz, B.G. Allen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-04-01
Schriftenreihe:	Redox Biology
Schlagworte:	Superoxide dismutase mimetic Avasopasem manganese GC4419 Cisplatin Radiation Kidney injury
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213231722003718
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