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Epigenomic profiling of immune cell subtypes reveals H3K27ac-marked stress signatures after long-duration spaceflight

Abstract Long-duration spaceflight imposes significant physiological stress on astronauts, including profound alterations in immune function. This study investigated epigenetic changes in immune cells following prolonged orbital spaceflight by analysing histone modifications in CD4+ and CD8+ T-cells...

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Principais autores: Tabea L. Fullstone, Lukas F.J. Fischer, Maria Bohmeier, Petra Frings-Meuthen, Brian E. Crucian, Philipp Rathert
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2025-09-01
Serija:Scientific Reports
Online dostop:https://doi.org/10.1038/s41598-025-17930-1
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