Targeting VDR–RXR heterodimerization in neurodegenerative diseases: a hypothetical framework for combined vitamin D3 and vitamin A therapy

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease are characterized by progressive neuronal loss, oxidative stress, and limited treatment options. While vitamin D₃ has demonstrated neuroprotective potential, we hypothesize that its co-administration with vitamin A may enhance th...

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Main Authors:	Mujittapha Umar Sirajo, Rukevwe Obie, Abubakar I. Mukhtar, Nasiru M. Abdullahi, Enaohwo M. Taniyohwo, John C. Oyem, Ibrahim M. Badamasi
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-04-01
Series:	Frontiers in Neurology
Subjects:	Alzheimer’s disease Parkinson’s disease neuroprotection VDR–RXR heterodimer vitamin A vitamin D3
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2026.1754364/full
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