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The role of SWI/SNF chromatin remodelers in the repair of DNA double strand breaks and cancer therapy

Switch/Sucrose non-fermenting (SWI/SNF) chromatin remodelers hydrolyze ATP to push and slide nucleosomes along the DNA thus modulating access to various genomic loci. These complexes are the most frequently mutated epigenetic regulators in human cancers. SWI/SNF complexes are well known for their fu...

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Principais autores: Maria Sadek, Anand Sheth, Grant Zimmerman, Emily Hays, Renier Vélez-Cruz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-12-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
chromatin remodelers
homologous recombination
double strand break repair
cancer therapy
DNA end resection
SWI/SNF
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2022.1071786/full
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