Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-, anion-, or non-selective ion channel,...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Wenlei Ye, Tina W Han, Mu He, Yuh Nung Jan, Lily Yeh Jan
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	eLife Sciences Publications Ltd 2019-07-01
Sarja:	eLife
Aiheet:	TMEM16F scramblase ion selectivity calcium-activated chloride channel small-conductance cation channel
Linkit:	https://elifesciences.org/articles/45187
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