Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
Bach2 limits T cell effector functions. Here the authors show that Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production, and describe mechanisms of negative feedback by which Bach2 restricts Baft-mediated Th2 response.
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| Principais autores: | , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2016-09-01
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| Colecção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/ncomms12596 |
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