Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction

Abstract Tauopathies such as Alzheimer’s disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. Tau’s pathological changes are closely linked to neurodegeneration, making tau a prime candidate for intervention. We developed an approach to mo...

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Autori principali:	Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brandt
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-02-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-45851-6
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