An Engineered Microvirin Variant with Identical Structural Domains Potently Inhibits Human Immunodeficiency Virus and Hepatitis C Virus Cellular Entry

Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of...

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Hlavní autoři:	Munazza Shahid, Amina Qadir, Jaewon Yang, Izaz Ahmad, Hina Zahid, Shaper Mirza, Marc P. Windisch, Syed Shahzad-ul-Hussan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-02-01
Edice:	Viruses
Témata:	microvirin lectin human immunodeficiency virus hepatitis c virus antiviral inhibitor non-immunogenic viral entry protein drugs lums1
On-line přístup:	https://www.mdpi.com/1999-4915/12/2/199
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