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Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors.

Adeno-associated viruses (AAV) are considered non-pathogenic in humans, and thus have been developed into powerful vector platforms for in vivo gene therapy. Although the various AAV serotypes display broad tropism, frequently infecting multiple tissues and cell types, vectors for specific and effic...

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Detalhes bibliográficos
Principais autores: Martin V Hamann, Niklas Beschorner, Xuan-Khang Vu, Ilona Hauber, Ulrike C Lange, Bjoern Traenkle, Philipp D Kaiser, Daniel Foth, Carola Schneider, Hildegard Büning, Ulrich Rothbauer, Joachim Hauber
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2021-01-01
coleção:PLoS ONE
Acesso em linha:https://doi.org/10.1371/journal.pone.0261269
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