FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels

It has been proposed that bile acid suppression of CYP7A1 gene expression is mediated through a gut-liver signaling pathway fibroblast growth factor (FGF)15/19-fibroblast growth factor receptor 4 which is initiated by activation of farnesoid X receptor in the ileum but not in the liver. This study e...

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Autori principali:	Quan Shang, Grace L. Guo, Akira Honda, Monica Saumoy, Gerald Salen, Guorong Xu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2013-10-01
Serie:	Journal of Lipid Research
Soggetti:	fibroblast growth factor 15 fibroblast growth factor 19 regulation bile acid
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520352871
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