KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC

Summary: The KRASG12D inhibitor MRTX1133 shows the potential to revolutionize the treatment paradigm for pancreatic ductal adenocarcinoma (PDAC), yet presents challenges. Our findings indicate that KRASG12D remodels a pentose phosphate pathway (PPP)-dominant central carbon metabolism pattern, facili...

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Hlavní autoři:	Xiangyan Jiang, Tao Wang, Bin Zhao, Haonan Sun, Yuman Dong, Yong Ma, Zhigang Li, Yuxia Wu, Keshen Wang, Xiaoying Guan, Bo Long, Long Qin, Wengui Shi, Lei Shi, Qichen He, Wenbo Liu, Mingdou Li, Lixia Xiao, Chengliang Zhou, Hui Sun, Jing Yang, Junhong Guan, Huinian Zhou, Zeyuan Yu, Zuoyi Jiao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-02-01
Edice:	Cell Reports Medicine
Témata:	KRASG12D MRTX1133 pentose phosphate pathway metabolic reprogramming pancreatic ductal adenocarcinoma
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666379125000394
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