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Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Mutations in genes encoding subunits of the cohesin complex are common in several cancers, but may also expose druggable vulnerabilities. We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SMC3, RAD21, and STAG2 and screened for synthetic lethality wit...

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Principais autores: Chue Vin Chin, Jisha Antony, Sarada Ketharnathan, Anastasia Labudina, Gregory Gimenez, Kate M Parsons, Jinshu He, Amee J George, Maria Michela Pallotta, Antonio Musio, Antony Braithwaite, Parry Guilford, Ross D Hannan, Julia A Horsfield
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2020-12-01
Serier:eLife
Fag:
cohesin
synthetic lethal
wnt signaling
drug screen
transcription
Online adgang:https://elifesciences.org/articles/61405
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