Efficient and versatile multiplex prime editing in hexaploid wheat
Abstract Prime editing is limited by low efficiency in plants. Here, we develop an upgraded engineered plant prime editor in hexaploid wheat, ePPEplus, by introducing a V223A substitution into reverse transcriptase in the ePPEmax* architecture. ePPEplus enhances the efficiency by an average 33.0-fol...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2023-06-01
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| Serie: | Genome Biology |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s13059-023-02990-1 |
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