Ultrasounds induce blood–brain barrier opening across a sonolucent polyolefin plate in an in vitro isolated brain preparation

Abstract The blood–brain barrier (BBB) represents a major obstacle to the delivery of drugs to the central nervous system. The combined use of low-intensity pulsed ultrasound waves and intravascular microbubbles (MB) represents a promising solution to this issue, allowing reversible disruption of th...

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Hlavní autoři:	Laura Librizzi, Laura Uva, Luca Raspagliesi, Matteo Gionso, Maria Cristina Regondi, Giovanni Durando, Francesco DiMeco, Marco de Curtis, Francesco Prada
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2022-02-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-022-06791-7
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