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nCas9 Engineering for Improved Target Interaction Presents an Effective Strategy to Enhance Base Editing

Abstract Base editors (BEs) are a recent generation of genome editing tools that couple a cytidine or adenosine deaminase activity to a catalytically impaired Cas9 moiety (nCas9) to enable specific base conversions at the targeted genomic loci. Given their strong application potential, BEs are under...

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Principais autores: Guiquan Zhang, Ziguo Song, Shisheng Huang, Yafeng Wang, Jiayuan Sun, Lu Qiao, Guanglei Li, Yuanyuan Feng, Wei Han, Jin Tang, Yulin Chen, Xingxu Huang, Furui Liu, Xiaolong Wang, Jianghuai Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2024-08-01
coleção:Advanced Science
Assuntos:
base editor
enhanced BE
nCas9 engineering
non‐targeted strand
T‐cells
Acesso em linha:https://doi.org/10.1002/advs.202405426
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