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circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation

Abstract Background The BCR-ABL fusion protein is the key factor that results in the occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR-ABL to achieve complete remission. However, remission failure occurs due to acquired resistance caused by secondary BCR-ABL...

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Principais autores: Jianming Wang, Yang Liang, Yuefeng Qin, Guoyun Jiang, Yuhang Peng, Wenli Feng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-09-01
Serier:Journal of Translational Medicine
Fag:
Chronic myeloid leukemia
circCRKL
Proliferation
BCR-ABL
ceRNA
Online adgang:https://doi.org/10.1186/s12967-022-03586-2
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