G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells

Abstract Background The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2–7 (EGFRvIII) being amongst the most common genomic mutations. EGFRvIII is heterogeneously expressed in GBM. We already showed that...

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Autores principales:	Meryem H. Cetin, Thorsten Rieckmann, Konstantin Hoffer, Britta Riepen, Sabrina Christiansen, Fruzsina Gatzemeier, Simon Feyerabend, Melanie Schoof, Ulrich Schüller, Cordula Petersen, Martin Mynarek, Kai Rothkamm, Malte Kriegs, Nina Struve
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-01-01
Colección:	Radiation Oncology
Materias:	Glioblastoma EGFRvIII Wee1 inhibition Adavosertib X-irradiation Radiosensitization
Acceso en línea:	https://doi.org/10.1186/s13014-023-02210-x
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