IL-11/IL-11R signal inhibition by 9MW3811 remodels immune tumor microenvironment and enhances anti-tumor efficacy of PD-1 blockade

Abstract Recent studies have uncovered evidences for pro-tumorigenic activities attributed to IL-11, prompting a renewed focus on therapeutic strategies targeting IL-11 signaling for anti-tumor treatment. Here, we introduce 9MW3811, a monoclonal antibody designed to neutralize IL-11 effectively. By...

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Detalhes bibliográficos

Principais autores:	Chang Zhang, Shasha Jiao, Dadi Zeng, Wen Jiang, Rongjuan Wang, Bin Zheng, Min Wang, Shuang Wang, Xun Gui
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-05-01
coleção:	npj Precision Oncology
Acesso em linha:	https://doi.org/10.1038/s41698-025-00913-w
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