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Enhancing reprogramming towards induced human expanded pluripotency through substitution of SOX2 with engineered SOX17 transcription factors

Abstract Expanded potential stem cells (EPSCs) represent a distinct and developmentally primitive stem cell population characterized by their broad developmental potential, which encompasses both embryonic and extra-embryonic lineages. In this study, we employed a polycistronic cassette to directly...

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Bibliographic Details
Main Authors: Haoqing Hu, Derek Hoi Hang Ho, Shi Wing Yeung, Yuebin Tan, Sik Yin Ho, Mingxi Weng, Degong Ruan, Ralf Jauch
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-026-09963-7
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