Distinct impacts of alpha-synuclein overexpression on the hippocampal epigenome of mice in standard and enriched environments

Elevated alpha-synuclein (SNCA) gene expression is associated with transcriptional deregulation and increased risk of Parkinson's disease, which may be partially ameliorated by environmental enrichment. At the molecular level, there is emerging evidence that excess alpha-synuclein protein (aSyn) imp...

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Hauptverfasser:	Samantha L. Schaffner, Zinah Wassouf, Thomas Hentrich, Melanie Nuesch-Germano, Michael S. Kobor, Julia M. Schulze-Hentrich
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-10-01
Schriftenreihe:	Neurobiology of Disease
Schlagworte:	Alpha-synuclein Epigenetics Multiomics integration Gene-environment interaction
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0969996123002899
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