Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters

A set of 6- to 24-valent clusters was constructed with terminal deoxynojirimycin (DNJ) inhibitory heads through C6 or C9 linkers by way of Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions between mono- or trivalent azido-armed iminosugars and calix[8]arene scaffolds differing in their va...

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Principais autores:	Jérémy P. Schneider, Stefano Tommasone, Paolo Della Sala, Carmine Gaeta, Carmen Talotta, Céline Tarnus, Placido Neri, Anne Bodlenner, Philippe Compain
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2020-11-01
叢編:	Pharmaceuticals
主題:	multivalency inhibitory multivalent effect CuAAC calix[8]arene α-mannosidase
在線閱讀:	https://www.mdpi.com/1424-8247/13/11/366
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