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Protein residue network analysis reveals fundamental properties of the human coagulation factor VIII

Abstract Hemophilia A is an X-linked inherited blood coagulation disorder caused by the production and circulation of defective coagulation factor VIII protein. People living with this condition receive either prophylaxis or on-demand treatment, and approximately 30% of patients develop inhibitor an...

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Bibliografiske detaljer
Principais autores: Tiago J. S. Lopes, Ricardo Rios, Tatiane Nogueira, Rodrigo F. Mello
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2021-06-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-021-92201-3
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