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Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients

Abstract Methylation of the O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter is predictive for treatment response in glioblastoma patients. However, precise predictive cutoff values to distinguish “MGMT methylated” from “MGMT unmethylated” patients remain highly debated in terms of pyroseque...

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Principais autores: Josefine Radke, Arend Koch, Fabienne Pritsch, Elisa Schumann, Martin Misch, Claudia Hempt, Klaus Lenz, Franziska Löbel, Fabienne Paschereit, Frank L. Heppner, Peter Vajkoczy, Randi Koll, Julia Onken
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-06-01
coleção:Acta Neuropathologica Communications
Assuntos:
Glioblastoma
Temozolomide (TMZ)
O(6)-Methylguanine-DNA methyltransferase (MGMT)
Methylation specific PCR (MSP)
Pyrosequencing (PSQ)
IDH (isocitrate dehydrogenase)
Acesso em linha:http://link.springer.com/article/10.1186/s40478-019-0745-z
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