CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome

ARID1B haploinsufficiency induced by missense or nonsense mutations of ARID1B is a cause of Coffin-Siris syndrome (CSS), a neurodevelopmental disorder associated with intellectual disability. At present, no appropriate human stem cell model for ARID1B-associated CSS has been reported. Here, we descr...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Tom Boerstler, Holger Wend, Mandy Krumbiegel, Atria Kavyanifar, André Reis, Dieter Chichung Lie, Beate Winner, Soeren Turan
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2020-08-01
Цуврал:	Stem Cell Research
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S1873506120301902
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!