A novel role of secreted methionine adenosyltransferase α2 in colorectal liver metastases

Abstract Background Colorectal liver metastasis (CRLM) occurs frequently in patients with colorectal cancer (CRC). Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosylmethionine, the principal methyl donor. MAT1A (encodes MATα1) is expressed mainly in normal adult liver, wherea...

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Autors principals:	Monica Justo, Youngyi Lim, Heping Yang, Andrea Floris, Swati Chandla, Manisha Dagar, Alexandra Gangi, Edwin Posadas, Mouad Edderkaoui, Stephen Pandol, Neil Bhowmick, Maria Lauda Tomasi, Shelly C. Lu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-12-01
Col·lecció:	Journal of Experimental & Clinical Cancer Research
Matèries:	Colorectal cancer Colorectal liver metastasis Extracellular vesicles Exosomes FAK Hepatocytes
Accés en línia:	https://doi.org/10.1186/s13046-025-03599-x
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