The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson′s disease

In this study, we investigated the effect of an antibody against E3 ubiquitin ligase seven in absentia homolog 1 (SIAH-1) in PC12 cells. 1-Methyl-4-phenylpyridinium (MPP + ) treatment increased α-synuclein, E1 and SIAH-1 protein levels in PC12 cells, and it reduced cell viability; however, there was...

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Hlavní autoři:	Zeng-lin Cai, Jing Xu, Shou-ru Xue, Yuan-yuan Liu, Yong-jin Zhang, Xin-zhi Zhang, Xuan Wang, Fang-ping Wu, Xiao-min Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wolters Kluwer Medknow Publications 2015-01-01
Edice:	Neural Regeneration Research
Témata:	nerve regeneration; neurodegeneration; Parkinson′s disease; ubiquitin-proteasome system; autophagy; E3 ubiquitin ligase seven in absentia homolog 1; 1-methyl-4-phenylpyridinium; rapamycin; neural regeneration
On-line přístup:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=8;spage=1286;epage=1291;aulast=Cai
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