Generation of six hiPSC lines from patients with WDR45-related neurodegenerative disease (Beta-propeller Protein-Associated Neurodegeneration, BPAN)

WDR45 encodes WIPI-4, a β-propeller scaffold protein involved in autophagy regulation. Pathogenic variants in WDR45 lead to β-propeller protein-associated neurodegeneration (BPAN), a form of neurodegeneration with brain iron accumulation (NBIA). Through an integration-free reprogramming approach, we...

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Autores principales:	Johana Tournois, Laure Chatrousse, Karine Giraud-Triboult, Justine Rousselot, Lina El Kassar, Léa Lesueur, Hamel Mahiou, Margot Bouquier, Ludivine Walter, Bertrand Mollereau, Anaïs Beaumont, Vincent des Portes, Anne-Lise Poulat, Gaetan Lesca, Alexandra Benchoua
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-08-01
Colección:	Stem Cell Research
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1873506126000814
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