Tumor sequencing before and after neoadjuvant chemoradiotherapy in locally advanced rectal cancer: Genetic tumor characterization and clinical outcome

Background and purpose: Neoadjuvant chemoradiotherapy (NCRT) is a standard treatment option for locally advanced rectal cancer. However, there is still conflicting data about the genetic landscape and potential dynamics during and after NCRT. This study evaluated oncogenic driver mutations before NC...

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Autors principals:	Kerstin Clasen, Nadja Ballin, Leon Schütz, Irina Bonzheim, Olga Kelemen, Michael Orth, Cihan Gani, Olaf Rieß, Stephan Ossowski, Maximilian Niyazi, Christopher Schroeder
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-01-01
Col·lecció:	Clinical and Translational Radiation Oncology
Matèries:	Radiotherapy Next-generation sequencing Tumor mutational burden KRAS TP53 ATM
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S240563082400171X
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