Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Abstract Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detec...

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Principais autores:	Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A. L. Menke, Istvan N. Huszar, Mark Jenkinson, Benjamin C. Tendler, Chaoyue Wang, Saad Jbabdi, Martin R. Turner, Karla L. Miller, Olaf Ansorge
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-03-01
coleção:	BMC Neuroscience
Assuntos:	Amyotrophic lateral sclerosis Magnetic resonance imaging Post mortem brain Systematic sampling Histology MRI-histology correlation
Acesso em linha:	http://link.springer.com/article/10.1186/s12868-018-0416-1
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