Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination

BackgroundThe myelin sheath ensures efficient nerve impulse transmission along the axons. Remyelination is a spontaneous process that restores axonal insulation, promoting neuroprotection and recovery after myelin damage. There is an urgent need for new pharmacological approaches to remyelination an...

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Prif Awduron:	Antonella Damiana Recchia, Alessandra Dominicis, Vincenzo Maria D'Amore, Tommaso Fabiano, Aland Ibrahim Ahmed Al Jaf, Simone Peria, Francesco Basoli, Alberto Rainer, Luciana Marinelli, Francesco Saverio Di Leva, Antonella Ragnini-Wilson
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2024-10-01
Cyfres:	Frontiers in Molecular Neuroscience
Pynciau:	remyelination oligodendrocytes glucocorticoids molecular docking & molecular dynamics (MD) simulation glia cells hedgehog (Hh)
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fnmol.2024.1473960/full
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