Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC

Despite the efforts, pancreatic ductal adenocarcinoma (PDAC) is still highly lethal. Therapeutic challenges reside in late diagnosis and establishment of peculiar tumor microenvironment (TME) supporting tumor outgrowth. This stromal landscape is highly heterogeneous between patients and even in the...

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Principais autores:	Chiara Musiu, Francesca Lupo, Antonio Agostini, Gabriella Lionetto, Michele Bevere, Salvatore Paiella, Carmine Carbone, Vincenzo Corbo, Stefano Ugel, Francesco De Sanctis
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2024-05-01
Series:	Frontiers in Immunology
Assuntos:	PDAC - pancreatic ductal adenocarcinoma immunotherapy TME (tumor microenvironment) cancer associated fibroblast (CAF) MDSC (myeloid-derived suppressor cells) TILs (tumor infiltrating lymphocytes)
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341079/full
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