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Host protein cleavage by Dengue and Zika virus NS3 proteases: from substrate identification to potential biological consequences

Dengue virus (DENV) and Zika virus (ZIKV) are medically important orthoflaviviruses that utilize the multifunctional NS3 protease, in complex with its cofactor NS2B, for viral replication and host modulation. Here, we summarize current knowledge of host proteins targeted by NS3 proteases and discuss...

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Autors principals: Umar Saidu, Bbumba Patrick, Wen-Chi Su
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2026-07-01
Col·lecció:Frontiers in Cellular and Infection Microbiology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fcimb.2026.1899950/full
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