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Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target

Summary: Leucine-rich repeat containing 25 (LRRC25), a type I membrane protein, is specifically expressed in myeloid cells including neutrophils and macrophages. The anti-inflammatory role of LRRC25 was suggested in a few pathogenic models. However, its role in cancer immunity has not been interroga...

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Autors principals: Guorong Zhang, Hanzhi Yu, Jingjing Liu, Ge Dong, Zhigang Cai
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2025-05-01
Col·lecció:Cell Reports
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S2211124725004024
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