Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition.

<h4>Background</h4>Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure. Despite the scarce number of resistant clinical isolates, MIL-resistance by mutations in a sin...

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Detalhes bibliográficos

Principais autores:	Dimitri Bulté, Lieselotte Van Bockstal, Laura Dirkx, Magali Van den Kerkhof, Carl De Trez, Jean-Pierre Timmermans, Sarah Hendrickx, Louis Maes, Guy Caljon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2021-07-01
coleção:	PLoS Neglected Tropical Diseases
Acesso em linha:	https://doi.org/10.1371/journal.pntd.0009622
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