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Upregulation of miR-146a-5p and miR-146b-5p limits IL-1β-mediated signaling in adipose tissue during polytrauma by downregulating IRAK1

MicroRNAs (miRNAs) are small non-coding RNAs and play a crucial role in the regulation of inflammation. White adipose tissue (WAT) covers the body and internal organs in subcutaneous and visceral fat depots, respectively, and represents an important source of circulating miRNAs. The role of WAT and...

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Principais autores: Antonia Mortsch, Julian Roos, Rebecca Halbgebauer, Ludmila Lupu, Annette Palmer, Anja Werberger, Ulrich Stifel, Martin Wabitsch, Markus Huber-Lang, Julia Zinngrebe, Pamela Fischer-Posovszky
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Immunology
Fag:
adipocytes
adipose tissue
interleukin-1
miRNAs
polytrauma
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1658504/full
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