Physicochemical convergence in antibody CDR3-VH repertoires recognizing phosphorothioate-modified oligonucleotides backbone

IntroductionThe development of recombinant antibody binders against phosphorothioate-modified antisense oligonucleotides (PS-ASOs) remains challenging due to the highly polyanionic character and structural flexibility of the phosphorothioate backbone. Here, we applied a next-generation sequencing (N...

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Autors principals:	Riccardo Galasso, Francesco Coppolino, Alessia Berbiglia, Grete Francesca Privitera, Agata Famà, Giuseppe Valerio De Gaetano, Germana Lentini, Concetta Beninati
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Immunology
Matèries:	antisense oligonucleotides complementarity-determining region next generation sequencing phosphorothioate modifications physicochemical signatures single-chain variable fragments
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1843118/full
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