Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward

Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR). KOR agonists have been shown to encode dysphoria, aversion, and changes in rewa...

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Prif Awduron:	Antony D. Abraham, Sanne M. Casello, Benjamin B. Land, Charles Chavkin
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2022-03-01
Cyfres:	Addiction Neuroscience
Pynciau:	Stress Dopamine Cocaine Kappa opioid receptors Dynorphin Dorsal raphe nucleus
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2772392522000013
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!