Leptin enhances the efficacy of glucantime to modulate macrophage polarization toward the M1 phenotype in Leishmania tropica-infected macrophages

Abstract Background Macrophages are essential immune cells during Leishmania infection, as their polarization toward M1/M2 phenotypes determines disease outcome. This study aimed to investigate the modulatory effects of leptin, alone and in combination with glucantime, on macrophage polarization in...

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Ngā kaituhi matua:	Alireza Keyhani, Abdollah Jafarzadeh, Iraj Sharifi, Ehsan Salarkia
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-08-01
Rangatū:	Parasites & Vectors
Ngā marau:	Leishmaniasis Leishmania tropica Macrophages M1/M2 macrophages Leptin Glucantime
Urunga tuihono:	https://doi.org/10.1186/s13071-025-07004-6
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!