Isaridin E Protects against Sepsis by Inhibiting Von Willebrand Factor-Induced Endothelial Hyperpermeability and Platelet–Endothelium Interaction

Endothelial hyperpermeability is pivotal in sepsis-associated multi-organ dysfunction. Increased von Willebrand factor (vWF) plasma levels, stemming from activated platelets and endothelium injury during sepsis, can bind to integrin αvβ3, exacerbating endothelial permeability. Hence, targeting this...

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Autores principales:	Yao-Sheng Liu, Wen-Liang Chen, Yu-Wei Zeng, Zhi-Hong Li, Hao-Lin Zheng, Ni Pan, Li-Yan Zhao, Shu Wang, Sen-Hua Chen, Ming-Hua Jiang, Chen-Chen Jin, Yu-Chen Mi, Zhao-Hui Cai, Xin-Zhe Fang, Yong-Jun Liu, Lan Liu, Guan-Lei Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2024-06-01
Colección:	Marine Drugs
Materias:	sepsis endothelial hyperpermeability von Willebrand factor isaridin E acute lung injury
Acceso en línea:	https://www.mdpi.com/1660-3397/22/6/283
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