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Protective effects of pyrroloquinoline quinone in brain folate deficiency

Abstract Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC). Cerebral folate uptake primarily occurs at the blo...

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Sparad:
Huvudupphov: Vishal Sangha, Sara Aboulhassane, Qing Rui Qu, Reina Bendayan
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2023-11-01
Serie:Fluids and Barriers of the CNS
Ämnen:
Pyrroloquinoline quinone
Reduced folate carrier
Proton-coupled folate transporter
Neuroinflammation
Oxidative stress
Mitochondrial function
Länkar:https://doi.org/10.1186/s12987-023-00488-3
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