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Telomere occupancy by TRF2 is altered by KIT mutations and correlates with mastocytosis regression

Abstract Mastocytosis, a clonal disorder characterized by the accumulation of mast cells in various tissues, affects both adults and children. Adults frequently exhibit KIT activating mutations, usually in the phospho-transferase domain (PTD KIT mutations). Our previous findings revealed that childr...

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Principais autores: Julie Bruneau, Sophie Georgin-Lavialle, Sophia Ladraa, Zakia Belaid, Isabelle Plo, Sébastien Letard, Erinn Soucie, Irena Draskovic, Nicolas Goudin, Marie Bouillié, Yves Lepelletier, Julien Rossignol, Laura Polivka, Laurent Frenzel, Olivier Lortholary, Sylvie Fraitag, Christine Bodemer, Patrick Revy, Michel Arock, Thierry-Jo Molina, Arturo Londono-Vallejo, Patrice Dubreuil, Leila Maouche-Chretien, Olivier Hermine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2025-11-01
coleção:Blood Cancer Journal
Acesso em linha:https://doi.org/10.1038/s41408-025-01372-z
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