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Genomic GC bias correction improves species abundance estimation from metagenomic data

Abstract Metagenomic sequencing measures the species composition of microbial communities and has revealed the crucial role of microbiomes in the etiology of a range of diseases such as colorectal cancer. Quantitative comparisons of microbial communities are, however, affected by GC-content-dependen...

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Autori principali: Laurenz Holcik, Arndt von Haeseler, Florian G. Pflug
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-11-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-025-65530-4
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