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EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers

Abstract Exonuclease EXO1 performs multiple roles in DNA replication and DNA damage repair (DDR). However, EXO1 loss is well-tolerated, suggesting the existence of compensatory mechanisms that could be exploited in DDR-deficient cancers. Using CRISPR screening, we find EXO1 loss as synthetic lethal...

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Kaydedildi:
Asıl Yazarlar: Marija Maric, Sandra Segura-Bayona, Raviprasad Kuthethur, Tohru Takaki, Valerie Borel, Tyler H. Stanage, Miroslav P. Ivanov, Nishita Parnandi, Graeme Hewitt, Rhona Millar, Carmen S. Fonseca, Harshil Patel, Miriam Llorian, Scott Warchal, Michael Howell, Arnab Ray Chaudhuri, Panagiotis Kotsantis, Simon J. Boulton
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2025-09-01
Seri Bilgileri:Nature Communications
Online Erişim:https://doi.org/10.1038/s41467-025-63349-7
Etiketler: Etiketle
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