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The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology. We thus generated mice with a specific knockout o...

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Principais autores: Emilie Ronin, Martina Lubrano di Ricco, Romain Vallion, Jordane Divoux, Ho-Keun Kwon, Sylvie Grégoire, Davi Collares, Angéline Rouers, Véronique Baud, Christophe Benoist, Benoit L. Salomon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-10-01
coleção:Frontiers in Immunology
Assuntos:
regulatory T cells
NF-κB
autoimmunity
stability
activation
relA
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.02487/full
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