Targeting <i>Penicillium expansum</i> GMC Oxidoreductase with High Affinity Small Molecules for Reducing Patulin Production

Flavine adenine dinucleotide (FAD) dependent glucose methanol choline oxidoreductase (GMC oxidoreductase) is the terminal key enzyme of the patulin biosynthetic pathway. GMC oxidoreductase catalyzes the oxidative ring closure of (<i>E</i>)-ascladiol to patulin. Currently, no protein involved in the...

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Detalles Bibliográficos

Principais autores:	Vincenzo Tragni, Pietro Cotugno, Anna De Grassi, Maria Maddalena Cavalluzzi, Annamaria Mincuzzi, Giovanni Lentini, Simona Marianna Sanzani, Antonio Ippolito, Ciro Leonardo Pierri
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2020-12-01
Series:	Biology
Assuntos:	<i>Penicillium expansum</i> GMC oxidoreductase patulin biosynthesis contamination prevention mycotoxin production inhibition comparative 3D modeling virtual screening of chemical libraries
Acceso en liña:	https://www.mdpi.com/2079-7737/10/1/21
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