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Monobac System–A Single Baculovirus for the Production of rAAV

Large-scale manufacturing of rAAV is a bottleneck for the development of genetic disease treatments. The baculovirus/Sf9 cell system underpins the first rAAV treatment approved by EMA and remains one of the most advanced platforms for rAAV manufacturing. Despite early successes, rAAV is still a comp...

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Autori principali: Lionel Galibert, Aurélien Jacob, Adrien Savy, Yohann Dickx, Delphine Bonnin, Christophe Lecomte, Lise Rivollet, Peggy Sanatine, Marjorie Boutin Fontaine, Christine Le Bec, Otto-Wilhelm Merten
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-08-01
Serie:Microorganisms
Soggetti:
rAAV
baculovirus
gene therapy
Accesso online:https://www.mdpi.com/2076-2607/9/9/1799
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