Discovery of putative natural compounds inhibitor of the germinant spore receptor CspC in Clostridioides difficile infection: Gaining insights via In silico and bioinformatics approach

A Gram-positive anaerobic bacillus known as Clostridioides difficile (C. difficile) present in the intestinal tract of humans is the causative organism for C. difficile infection (CDI). A prospective target for the therapy of CDI is the germinant spore receptor CspC, a key regulator of the germinati...

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Principais autores:	Oluwatosin A. Saibu, Gagandeep Singh, Damilola A. Omoboyowa, Adebimpe K Oyejoke, Sunday A. Olugbodi, Abayomi Bamisaye, Catherine B. Adeniji, Temitope M. Ajayi, Yetunde I. Akinpelu, Christianah A. Ogunwole, Osasenaga M. Ighodaro, Ann Christopher Francis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-01-01
Colecção:	Informatics in Medicine Unlocked
Assuntos:	Clostridioides difficile C. difficile infection Antimicrobial resistance ADMET Molecular docking Molecular dynamics simulation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352914823001855
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