Codi QR

The Marine-Derived Macrolactone Mandelalide A Is an Indirect Activator of AMPK

The mandelalides are complex macrolactone natural products with distinct macrocycle motifs and a bioactivity profile that is heavily influenced by compound glycosylation. Mandelalides A and B are direct inhibitors of mitochondrial ATP synthase (complex V) and therefore more toxic to mammalian cells...

Descripció completa

Guardat en:
Autors principals: Daphne R. Mattos, Xuemei Wan, Jeffrey D. Serrill, Minh H. Nguyen, Ian R. Humphreys, Benoit Viollet, Amos B. Smith, Kerry L. McPhail, Jane E. Ishmael
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2022-06-01
Col·lecció:Marine Drugs
Matèries:
OXPHOS
polyketide
ATP synthase
ATPase
oxidative phosphorylation
AMP-activated protein kinase
Accés en línia:https://www.mdpi.com/1660-3397/20/7/418
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars