Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of Natural Killer cell cytotoxicity

Cancer surgery while necessary for primary tumor removal, has been shown to induce immune suppression and promote metastases in preclinical models and human cancer surgery patients. Activating the immune system and reversing immunosuppression have emerged as promising ways to treat cancer and they c...

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Hauptverfasser:	Lee-Hwa Tai, Almohanad A. Alkayyal, Amanda L. Leslie, Shalini Sahi, Sean Bennett, Christiano Tanese de Souza, Katherine Baxter, Leonard Angka, Rebecca Xu, Michael A. Kennedy, Rebecca C. Auer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2018-06-01
Schriftenreihe:	OncoImmunology
Schlagworte:	myeloid derived suppressor cells metastases nk cell cytotoxicity postoperative immunosuppression sildenafil
Online-Zugang:	http://dx.doi.org/10.1080/2162402X.2018.1431082
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